What we actually use
The supplements I reach for most with clients, chosen for quality brands and the most usable forms.
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Jump to: MCAS & histamine · Fibromyalgia · Vitamins
MCAS & histamine
My go-to list for histamine intolerance and mast cell activation. Start low and add one thing at a time so you can tell what helps.
- Seeking Health DAO EnzymeThe enzyme that breaks down histamine from food. Taken right before meals.Amazon ↗
- Seeking Health ProBiota HistaminXA probiotic made only of strains that don't produce histamine, to support a calmer gut.Amazon ↗
- Apigenin 50 mg (NSF Certified)A calming flavonoid from chamomile that is often used to settle mast cells and support sleep.Amazon ↗
- Thorne Quercetin PhytosomeQuercetin helps steady mast cells. This phytosome form is absorbed much better than plain quercetin.Amazon ↗
- Thorne Buffered C (powder)Vitamin C helps your body clear histamine. The buffered form is gentle on the stomach.Amazon ↗
- Life Extension Discomfort Relief (PEA)Palmitoylethanolamide, a natural fat your body makes that helps quiet mast cells and pain signals.Amazon ↗
- Carlson Elite Omega-3 GemsHigh-quality fish oil to help balance prostaglandins, which often run high with mast cell issues.Amazon ↗
- Thorne Magnesium BisglycinateCalming magnesium in the glycinate form, which is easy on sensitive guts.Amazon ↗
- Thorne Basic B ComplexMethylated B vitamins (methylfolate and methylcobalamin), already in their active forms. Best if you tolerate methylated B's.Amazon ↗
- Seeking Health B MinusA B complex without folate or B12, for people who feel wired or worse on methylated B's.Amazon ↗
Not everyone does well on methylated B vitamins. If they leave you anxious, wired or achy, read Methyl Trapping and try the B Minus or folinic acid options instead.
Fibromyalgia
Support for energy production, muscles and a healthy inflammation response.
- Seeking Health Magnesium Malate (powder)Malate is the form most often used for muscle pain and low energy. The powder makes dosing easy.Amazon ↗
- Thorne Ubiquinol (CoQ10)CoQ10 in its active form, the first thing I reach for to support cellular energy.Amazon ↗
- D-Ribose PowderA simple sugar your cells use to rebuild their energy supply.Amazon ↗
- Thorne Acetyl-L-CarnitineHelps carry fat into your mitochondria to be burned for energy.Amazon ↗
- Thorne Alpha-Lipoic AcidAn antioxidant that supports mitochondria and nerve health.Amazon ↗
- Thorne CreatineSupports muscle energy and also spares your body's methyl donors.Amazon ↗
- Life Extension Discomfort Relief (PEA)Helps calm pain signaling and the mast cells involved in it.Amazon ↗
- Thorne Curcumin PhytosomeTurmeric's active compound in a well-absorbed form, for a healthy inflammation response.Amazon ↗
- Carlson Elite Omega-3 GemsOmega-3s support a healthy inflammation response.Amazon ↗
- Thorne Vitamin D/K2 LiquidLow vitamin D is common with chronic pain. Liquid drops make the dose easy to adjust.Amazon ↗
Vitamins in their most active forms
Two picks for each vitamin, choosing the form your body can use with the fewest conversion steps. That matters most when your genes slow down one of those steps.
Vitamin A
Preformed vitamin A (retinyl palmitate), so your body doesn't have to convert it from beta-carotene. This matters if you carry BCO1 variants.
Vitamin D3
D3 (cholecalciferol), the form your body makes from sunlight.
Vitamin E
Natural mixed forms rather than synthetic dl-alpha tocopherol.
Vitamin K2
K2 as MK-4 or MK-7, the forms that help direct calcium into bones.
Vitamin C
Buffered or liposomal forms are gentler and better absorbed.
B1 (Thiamine)
Fat-soluble thiamine forms that get into cells more easily.
B2 (Riboflavin)
Riboflavin 5'-phosphate, the active form. Helpful with MTHFR variants.
B3 (Niacin)
Nicotinamide riboside and niacinamide, which raise NAD+ without the niacin flush.
B5 (Pantothenic Acid)
Pantethine, the active form that sits closer to coenzyme A.
B6
Pyridoxal 5'-phosphate (P5P), the active form. B6 is also a helper for the DAO enzyme.
B7 (Biotin)
Biotin is already active as is; these are clean, well-made options.
B9 (Folate)
Methylfolate (5-MTHF) for most people, or folinic acid if methylated forms don't agree with you.
B12
Active B12 forms. Hydroxocobalamin is a gentler, non-methyl option.
- Seeking Health Active B12 (methyl + adenosyl)Amazon ↗
- Seeking Health Hydroxo B12 with Folinic AcidAmazon ↗
These products are listed for education, not as medical advice, and are not meant to diagnose, treat or cure any condition. Talk with your healthcare provider before starting a supplement, especially if you are pregnant or take medications. Doses on the label may not be right for you.
